NEW STEP BY STEP MAP FOR PKRRATING

The activated enzyme then phosphorylates its key substrate, the translational initiation variable eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to your conserved household of 4 protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in reaction to unique stimuli12, triggering the integrated pressure res